|
|
|
Diabetes 101 what you need to know about
One of the leading causes of death in the US is diabetes. It affects the way the body uses food after digestion, for growth and energy, known as metabolic disorder. If proper treatment and medication is not administered, at times aggressively, it...
Diabetes and Insulin
Diabetes and Insulin
Diabetes is a condition in which the body either does not
manufacture sufficient amounts of insulin or does not properly
use insulin. Insulin is a hormone made by the pancreas that is
necessary for the transport of sugar...
How to Follow a Diabetic Diet
There are approximately 1 million new patients diagnosed with
diabetes each year in the United States and over 200,000 deaths
attributed to the disease. If you have recently been one of the
patients diagnosed, you want to do everything you cannot...
Medicinal Properties of Bitter Melon - Good for Diabetics
Bitter Melon is the English name of Momordica charantia, a climbing vine whose leaves and green fruits, although bitter, has been used to fight cancer, diabetes and many infectious diseases. It is also a powerful weapon against HIV/AIDS since...
What Is Diabetes? What Are The Risks?
Your doctor may have recently advised you have diabetes. Or you are overweight and you have discovered you may be at risk of diabetes. Others may have a friend or family member who has been diagnosed with the disease. Just what does diabetes mean...
|
|
| |
|
|
|
|
Combination of Thiazide-Type Diuretic and Beta-Blocker may Cause Diabetes
Clinical Question: In patients with hypertension is it safe to combine thiazide-type diuretic and beta-blocker?
Bottom Line: Studies suggest that the routine combined use of a thiazide with a beta-blocker should be questioned in the early management of hypertension, particularly in patients who are at increased risk of developing new-onset diabetes. In such patients, the increased risk of developing diabetes may exceed the benefit of blood pressure lowering.
Reference: J Hypertens. 2005 Oct;23(10):1777-1781
Study Design: Retrieve randomized control trials and meta-analysis
Synopsis: Recently published trials addressing the pharmacological management of hypertension have reported an increase in new-onset diabetes mellitus when comparing certain older and newer treatment regimens. Thiazide-type diuretics (thiazides) and beta-blockers have been individually implicated, but these drugs are frequently combined, and the magnitude of risk associated with their combined use has not been quantified. So randomized control trials were retrieved that: (i) featured stepped treatment to manage hypertension; (ii) compared initial treatment using a thiazide or beta-blocker (older drug) with an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker or calcium antagonist (newer drug); (iii) assessed cardiovascular outcomes; (iv) reported new-onset diabetes; and (v) provided at least 1-year follow-up. A meta-analysis of available trials indicated that patients exposed to treatment regimens combining thiazides and beta-blockers are at greater risk of developing diabetes than regimens avoiding this combination of drugs (risk ratio for alternative therapy 0.81, 95% confidence interval 0.77-0.86). Current data cannot inform reliably about the risks associated with individual older drugs because of similar overall exposures in patients starting on newer and older drugs.
About the Author
A Certified Family Physician of the Philippine Academy of Family Physician and continue to complete the requirements for Continuing Medical Education in Family Practice. Also a member of the Philippine Medical Informatics Society, Philippine Occupational Health and Safety Inc., and Pangasinan Medical Society.
Faculty Department of Physiology (Medicine) Lyseum- Northwestern University, Dagupan, Pangasinan, Faculty Medical Informatics Lyseu
|
|
|
|
|
 |
